By Eric T. Wong

ISBN-10: 3319305743

ISBN-13: 9783319305745

ISBN-10: 331930576X

ISBN-13: 9783319305769

This concise textual content presents an entire review of alternating electrical fields treatment -- sometimes called tumor treating fields -- for glioblastoma and different varieties of sturdy tumor malignancies. Readers are given a primary figuring out of this novel anti-cancer therapy modality through studying from scientific trial information in addition to the actual and mobile biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.

Chapters illustrate the physics in the back of electrical box propagation in area and different media. this can be via a evaluate of our present knowing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the mobilephone floor chaperons that result in immunogenic cellphone loss of life. information from part III trials for the remedy of recurrent and newly clinically determined glioblastomas are integrated, in addition to a number of the ancillary post hoc analyses that have been played through numerous investigators. the rest of the bankruptcy covers different good tumor malignancies, together with non-small phone lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.

Alternating electrical Fields remedy in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, mobilephone biologists and mitosis researchers the basics wanted for scientific practice.

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Additional info for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields

Sample text

Lok and E. 7b) Unfortunately, biological tissues invariably exhibit nonlinear anisotropic behaviors, where Eqs. 7b must be modified and thus the relative permittivity stems from a generalized dielectric relaxation model as given by the Cole-Cole equation, Eq. 8) 1 -a Here, e ¥ and εs are the infinite-frequency and static permittivities, respectively, and τ is a time constant. α is the spectral shape parameter with values between 0 and 1 (Debye model). Real-world materials, including biological tissue, are dielectrics that to some extent have bound charges forming neutral atoms.

2 Fundamental Physics of Tumor Treating Fields 17 Fig. 2 Gauss’ law states that the electric flux ΦE or the flow of electric field is equal to the net sum of the varying electric field E over a closed surface area in a volume that encloses all the charges, Q. Here, nˆ represents the surface normal through a surface element dA. (A) The electric field lines generated by a positive point charge emanate from the center of the charge and impinge upon a Gaussian surface in an outward direction by convention.

A) The electric field lines generated by a positive point charge emanate from the center of the charge and impinge upon a Gaussian surface in an outward direction by convention. (B) The direction of electric field lines of a negative point charge point inward towards the center of charge by convention. Gauss’ law (Eq. 1a or Eq. 1b)  Gauss’ law mathematically states that the divergence of the electric field, E , is proportional to the space charge density ρ and inversely proportional to the permittivity of tissue or media ε, which is traversed by the electric charge.

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Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong


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