By Mary E. Brandt, Shawn R. Lockhart, David W. Warnock (auth.), Carol A. Kauffman, Peter G. Pappas, Jack D. Sobel, William E. Dismukes (eds.)
Essentials of scientific Mycology provides a finished review of the sphere of medical mycology. it's written for clinicians who take care of sufferers who've fungal infections. all of the significant systemic fungal infections is mentioned in regard to mycology, pathogenesis, epidemiology, scientific manifestations, prognosis, and remedy. The expanding antifungal armamentarium is defined extensive, and separate chapters evaluate expanding antifungal resistance and using mixture remedy. a piece is dedicated to high-risk sufferers who've obtained a stem phone or reliable organ transplant, are neutropenic, or have HIV an infection and who're at excessive possibility for constructing invasive fungal infections.
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Extra info for Essentials of Clinical Mycology
Such an approach to the selection of antifungal agents has become more reasonable with the development of a reliable and reproducible reference procedure for in vitro testing of fungal species against antifungal agents and the demonstration of correlations with clinical outcome, at least for some forms of candidiasis. However, the pitfalls of assuming a correlation between the results of susceptibility testing of other antifungal drugs and organisms in vitro and outcome in vivo should not be underestimated.
Aspergillus immunohistochemistry of culture-proven fungal tissue isolates shows high cross-reactivity. Pincus DH, Orenga S, Hotelier S. Yeast identification-past, present, and future methods. Rees JR, RW Pinner, RA Hajjeh, ME Brandt, AL Reingold. The epidemiological features of invasive mycotic infections in the San Francisco Bay area 1992–1993: results of population-based active surveillance. Perfect JR, Cox GM, Lee JY, et al. The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.
Varying degrees of success have been reported in the recovery of DNA from formalin-fixed tissues. The formalin fixation step has been reported to cause degradation of amplifiable DNA as a result of DNA cross-linking. In cases where DNA cannot be recovered, immunohistochemical staining of tissue may be helpful (see Histopathologic Examination). Molecular diagnostics offer great hope for the rapid detection and identification of difficult-to-culture organisms, for detection of antifungal drug resistance, and for rapid diagnosis directly from host tissues and fluids.
Essentials of Clinical Mycology by Mary E. Brandt, Shawn R. Lockhart, David W. Warnock (auth.), Carol A. Kauffman, Peter G. Pappas, Jack D. Sobel, William E. Dismukes (eds.)